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class="art-body"> <p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; visibility: visible; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(51, 51, 51); font-size: 15px; text-indent: 42px; background-color: transparent; caret-color:red line-height: 1.6em; font-family: Helvetica, Arial, sans-serif; visibility: visible;">上一節我們聊到其他各種模型方案各自的缺陷，包括難以形成特定的生理結構、無法發揮相對應的功能、形成的信號通路與人體不一致等。因此類器官培養體系的一大重點便是了解目標器官在體內的結構，盡可能完整的還原其在身體中的生長環境以及信號通路。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; visibility: visible; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(51, 51, 51); font-size: 15px; text-indent: 42px; background-color: transparent; caret-color:red line-height: 1.6em; font-family: Helvetica, Arial, sans-serif; visibility: visible;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"/></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; visibility: visible; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(51, 51, 51); font-size: 15px; text-indent: 42px; background-color: transparent; caret-color:red line-height: 1.6em; font-family: Helvetica, Arial, sans-serif; visibility: visible;">本篇將以腸道類器官為例，為大家簡要介紹腸道的結構與功能。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; visibility: visible; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"/></p><p><br/></p><section data-role="title" data-tools="135編輯器" data-id="124018" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: center; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: inline-block; transform-style: preserve-3d; visibility: visible;"><section style="margin: 0px 0px -4px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 18px; height: 3px; background-color: rgb(5, 70, 144); overflow: hidden; transform: translateZ(10px); visibility: visible;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"/> </section><section style="margin: 0px; padding: 7px 25px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(245, 248, 255); border-width: 1px; border-style: solid; border-color: rgb(5, 70, 144); visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144); transform: translateZ(5px); visibility: visible;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; font-family: Helvetica, Arial, sans-serif; visibility: visible;"><strong data-brushtype="text" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;">腸道的發育、結構及功能</strong></span> </section></section><section style="margin: -8px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: flex-end; transform: translateZ(10px); visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 7px; background-color: rgb(5, 70, 144); overflow: hidden; visibility: visible;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"/> </section></section></section></section></section><p><br/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(51, 51, 51); font-size: 15px; text-indent: 42px; background-color: transparent; caret-color:red line-height: 1.6em; font-family: Helvetica, Arial, sans-serif; visibility: visible;">腸道在功能和解剖學上分為小腸和大腸。小腸由十二指腸、空腸和回腸組成，而大腸由盲腸（包括闌尾）和結腸組成，結腸可進一步分為升結腸、橫結腸、降結腸和乙狀結腸。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; color: rgba(0, 0, 0, 0.9); text-align: center;" helvetica="" pingfang="" hiragino="" sans="" microsoft="" yahei="" font-size:="" letter-spacing:="" white-space:="" background-color:="" text-align:="" visibility:="" box-sizing:="" border-box="" overflow-wrap:="" break-word=""><img class="rich_pages wxw-img" data-backh="230" data-backw="526" data-galleryid="" data-ratio="0.43796296296296294" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_png/SJyibI36BxE0gkqUW6ojThNH4Zz6aT0cuu3IltoNJxcvibwO9Was9iazTGkCA1Z9HgFGia3z4j5n51ibzrpD6OqOnvQ/640?wx_fmt=png" data-type="png" data-w="1080" data-index="2" src="https://img61.chem17.com/9/20230420/638175940658961119899.png" _width="100%" crossorigin="anonymous" alt="圖片" data-fail="0" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; vertical-align: bottom; height: auto !important; width: 625px; visibility: visible !important;"/></p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; letter-spacing: 1.5px; text-align: justify; text-indent: 0em; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(51, 51, 51); font-size: 15px; text-indent: 42px; background-color: transparent; caret-color:red line-height: 1.6em; font-family: Helvetica, Arial, sans-serif; visibility: visible;"></span></section><p><br/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-align: center; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 12px; color: rgb(117, 117, 118); font-family: Helvetica, Arial, sans-serif; text-indent: 15px; box-sizing: border-box !important; overflow-wrap: break-word !important;">圖（A）（B）（C）小鼠腸道準備流程</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-align: center; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 12px; color: rgb(117, 117, 118); font-family: Helvetica, Arial, sans-serif; text-indent: 15px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-align: center; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><img class="rich_pages wxw-img" data-backh="275" data-backw="526" data-cropselx1="0" data-cropselx2="526" data-cropsely1="0" data-cropsely2="463" data-ratio="0.5222222222222223" data-src="https://mmbiz.qpic.cn/mmbiz_png/SJyibI36BxE0gkqUW6ojThNH4Zz6aT0cuv9LN3s0RxLGLyUKbSIiafyoKrFLQgvubUWaYLlzkVKxrgmN7qLfhxWg/640?wx_fmt=png" data-type="png" data-w="1080" data-index="3" src="https://img69.chem17.com/9/20230420/638175940663998400167.png" _width="100%" crossorigin="anonymous" alt="圖片" data-fail="0" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; vertical-align: inherit; height: auto !important; width: 625px; visibility: visible !important;"/><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(117, 117, 118); font-family: Helvetica, Arial, sans-serif; font-size: 12px; text-indent: 15px; background-color: transparent;"></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-align: center; text-indent: 15px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(117, 117, 118); font-size: 12px; background-color: transparent; caret-color:red font-family: Helvetica, Arial, sans-serif;"></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">腸道最主要的作用是從攝入的食物中吸收營養，其吸收功能主要由腸上皮吸收細胞膜刷狀緣中的特定營養轉運體介導（Daniel and Zietek，2015)，其中一些轉運體還可運輸藥物（Daniel and Kottra，2004)，功能上，食物消化后營養和礦物質的攝取發生在小腸。因此，大多數營養轉運體在十二指腸及空腸中表達（Wuensch et al.2013; Yoshikawa et al.2011)。腸道相關淋巴組織（gut associated lymphoid tissueGALT）在回腸聚集形成所謂派爾集合淋巴結（Peryers patches)，體現了腸道作為免疫器官的重要作用，而大腸主要負責液體的吸收，且容納了絕大多數的腸道微生物。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">幾乎整個胃腸道均起源于內胚層。在胚胎發育期間，十二指腸的近端部分（直至膽管入口）由前腸形成，消化道的大部分（從膽管到橫結腸的近端）由中腸形成，橫結腸遠端1/3、降結腸、乙狀結腸及直腸由后腸形成，位于胃腸道黏膜層的腸神經系統（enteric nervous system，ENS）調控腸道功能。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">胃腸壁本身由4層組成：黏膜層、黏膜下層、肌層及漿膜層（也稱外膜）。最外層也就是漿膜層或外膜，由結締組織組成，包裹肌層及肌間神經叢；黏膜下層由包含有大血管、神經管及神經的結締組織組成，將黏膜連接至肌層，并支持其功能。黏膜層是胃腸道的最內層，可進一步被細分為黏膜肌層（一層薄薄的平滑?。?、固有層（一層包含免疫細胞的結締組織）和上皮層（覆蓋腸道單層上皮細胞，形成宿主及管腔之間的屏障），多數消化、吸收及分泌過程均通過腸上皮細胞進行。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p><br/></p><section data-role="title" data-tools="135編輯器" data-id="124018" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: inline-block; transform-style: preserve-3d;"><section style="margin: 0px 0px -4px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 18px; height: 3px; background-color: rgb(5, 70, 144); overflow: hidden; transform: translateZ(10px);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section><section style="margin: 0px; padding: 7px 25px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(245, 248, 255); border-width: 1px; border-style: solid; border-color: rgb(5, 70, 144);"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144); transform: translateZ(5px);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong data-brushtype="text" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">小腸與結腸的區別</strong></span> </section></section><section style="margin: -8px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: flex-end; transform: translateZ(10px);"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 7px; background-color: rgb(5, 70, 144); overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; letter-spacing: 1.5px; text-align: justify; text-indent: 0em; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">近端腸管及遠端腸管的大體形態不同；</span></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; letter-spacing: 1.5px; text-align: justify; text-indent: 0em; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">腸上皮中存在不同亞型的腸上皮細胞：</span></section><p><br/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">1）干細胞負責每4—5天不斷更新上皮細胞；</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">2）潘氏細胞為位于隱窩底部的干細胞龕提供因子，同時分泌抗菌肽；</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">3）分泌黏蛋白的杯狀細胞可形成覆蓋上皮的黏液，構建物理屏障；</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">4）腸上皮吸收細胞可吸收營養和離子；</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">5）EECs可分泌多種激素，控制腸道運動并調節代謝；</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">6）含有味覺化學感受器的tuft細胞可參與免疫調節（Barker，2014)。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">需要注意的是，小腸上皮均有隱窩及絨毛，絨毛的長度從十二指腸到回腸逐漸增加；而結腸上皮僅有隱窩，沒有絨毛。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: center; text-indent: 0em; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><img class="rich_pages wxw-img" data-ratio="0.759927797833935" data-src="https://mmbiz.qpic.cn/mmbiz_png/SJyibI36BxE35p73EHtd52IzmkDPguG0Eb0jNBJwEnfmIysIXqxKvgntyXCBGrfTaN2ZQlBlCqo69GT1fB55LSw/640?wx_fmt=png" data-type="png" data-w="554" data-index="4" src="https://img69.chem17.com/9/20230420/638175940666536058405.png" _width="100%" crossorigin="anonymous" alt="圖片" data-fail="0" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; vertical-align: inherit; height: auto !important; width: 625px; visibility: visible !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-align: center; text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(117, 117, 118); font-family: Helvetica, Arial, sans-serif; font-size: 12px;">小腸上皮細胞構成示意圖</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; visibility: visible; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">在正常生理條件下，結腸遠端不存在潘氏細胞，剛才有提到潘氏細胞為位于隱窩底部的干細胞龕提供因子，同時分泌抗菌肽，這表明小腸和結腸的干細胞穩態存在差異。</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; background-color: transparent; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif; font-size: 15px;">這是小腸類器官培養過程中不需要添加Wnt蛋白，但結腸類器官培養基需要添加Wnt蛋白的核心原因。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 27px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p><br/></p><section data-role="title" data-tools="135編輯器" data-id="124018" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: inline-block; transform-style: preserve-3d;"><section style="margin: 0px 0px -4px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 18px; height: 3px; background-color: rgb(5, 70, 144); overflow: hidden; transform: translateZ(10px);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section><section style="margin: 0px; padding: 7px 25px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(245, 248, 255); border-width: 1px; border-style: solid; border-color: rgb(5, 70, 144);"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144); transform: translateZ(5px);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong data-brushtype="text" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">設計思路（小鼠腸道類器官）</strong></span> </section></section><section style="margin: -8px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: flex-end; transform: translateZ(10px);"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 7px; background-color: rgb(5, 70, 144); overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; letter-spacing: 1.5px; text-indent: 0em; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">腸道類器官主要有以下應用：</span></section><p><br/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">①建立器官發育與形態發生模型；</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">②建立疾病模型；</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">③再生醫學/精準醫學研究。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">單個干細胞或分離的腸道隱窩均可培養形成腸道類器官（Sato et al., 2009)。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p><br/></p><section data-role="title" data-tools="135編輯器" data-id="110073" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-family: system-ui, -apple-system, BlinkMacSystemFont, " helvetica="" pingfang="" hiragino="" sans="" microsoft="" yahei="" font-size:="" letter-spacing:="" text-align:="" white-space:="" background-color:="" color:="" box-sizing:="" border-box="" overflow-wrap:="" break-word=""><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: left;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: inline-block;"><section style="margin: 0px; padding: 0px 7px 0px 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; align-items: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; flex-shrink: 0;"><section style="margin: 7px -9px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 16px; height: 16px; background-color: rgb(5, 70, 144); flex-shrink: 0; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 16px; height: 16px; background-color: rgb(255, 207, 71); flex-shrink: 0; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section data-brushtype="text" style="margin: 0px 0px 0px 12px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 14px; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">一、生物微環境的設計</strong> </section></section><section data-width="100%" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 197px; height: 1px; background-color: rgb(5, 70, 144); overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section></section><p><br/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">類器官的體外3D培養需要適當的細胞外支架來支持細胞黏附并作為膜蛋白的配體來觸發調節細胞過程的信號，包括存活、遷移、增殖、活性維持和分化成特定譜系。支架是工程化的聚合生物材料，其支持類似于體內微環境的細胞組織，促進細胞重組為功能性組織，在此期間細胞分泌細胞外基質和酶，允許細胞通過周圍材料擴散和遷移。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-indent: 0em; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-align: center; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;"><img class="rich_pages wxw-img" data-backh="237" data-backw="445" data-ratio="0.5325842696629214" data-src="https://mmbiz.qpic.cn/mmbiz_png/SJyibI36BxE35p73EHtd52IzmkDPguG0ECYq4JEsBSe82nrzG4jVxYbo1hqG5AayFWQZP6Am8UQ1uMNhhGkVr6A/640?wx_fmt=png" data-type="png" data-w="445" data-index="5" src="https://img69.chem17.com/9/20230420/638175940667723982720.png" _width="100%" crossorigin="anonymous" alt="圖片" data-fail="0" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; vertical-align: inherit; height: auto !important; width: 625px; visibility: visible !important;"/></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-align: center; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px; color: rgb(117, 117, 118); font-family: Helvetica, Arial, sans-serif;">分布在各類細胞周圍的基底膜</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">3D類器官培養主要使用一種膠狀基質（商業上稱為基質膠），該基質是從Engelbreth-Holm-Swarm肉瘤小鼠腫瘤衍生的細胞系中分離出來的基質基礎上開發得到的膠狀基質（Liet al.1987)。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">目前在全球廣泛使用的品牌是美國康寧公司的Matrigel，由于其壟斷地位及需求的暴增導致產品產能不足，近年中國廈門?；镆餐瞥鐾町a品：Matrigengel，在類器官培養中也被國內外科學家廣泛使用。</span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: center;" helvetica="" pingfang="" hiragino="" sans="" microsoft="" yahei="" font-size:="" letter-spacing:="" white-space:="" background-color:="" color:="" text-align:="" box-sizing:="" border-box="" overflow-wrap:="" break-word=""><img class="rich_pages wxw-img" data-galleryid="" data-ratio="0.4722222222222222" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_png/SJyibI36BxE2dpMUSxTyXdKLeiceFrGypQ7FrXloKicfFz6wPw1ju746Cd9BITURFibpEu75fQBibibyFEXzOSuXSlrQ/640?wx_fmt=png" data-type="png" data-w="1080" data-index="6" src="https://img69.chem17.com/9/20230420/638175940670965135133.png" _width="677px" crossorigin="anonymous" alt="圖片" data-fail="0" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; vertical-align: bottom; height: auto !important; width: 677px !important; visibility: visible !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; color: rgba(0, 0, 0, 0.9); text-align: center;" helvetica="" pingfang="" hiragino="" sans="" microsoft="" yahei="" font-size:="" letter-spacing:="" white-space:="" background-color:="" text-align:="" box-sizing:="" border-box="" overflow-wrap:="" break-word=""><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(117, 117, 118); font-family: Helvetica, Arial, sans-serif;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">?；锘|膠</span></span></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; background-color: transparent; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif; font-size: 15px;">這種膠狀基質在1987年第一次被開發出來。1991年第一次被Aggeler用于乳腺上皮細胞的三維培養，其結構類似于乳腺組織中的腺泡結構（Aggeler et al., 1991)。</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; background-color: transparent; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif; font-size: 15px;">基于此，基質膠從此成為培養乳腺上皮細胞標準方法中的重要成分。</span><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; letter-spacing: 1.5px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); color: rgb(68, 91, 106); text-indent: 28px; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;">2009年Hans團隊首先利用基質膠構建了第一個類器官：上皮類器官，從此天然基質膠被廣泛用于類器官培養。</span></p><p><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; color: rgb(51, 51, 51); font-family: Helvetica, Arial, sans-serif;"><br/></span></p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; color: rgba(0, 0, 0, 0.9); font-family: system-ui, -apple-system, BlinkMacSystemFont, " helvetica="" pingfang="" hiragino="" sans="" microsoft="" yahei="" font-size:="" letter-spacing:="" text-align:="" white-space:="" background-color:="" visibility:="" overflow-wrap:="" break-word=""><section data-tools="135編輯器" data-id="121531" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: -1px 5px; padding: 15px 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; border-width: 1px; border-style: solid; border-color: rgb(5, 70, 144); visibility: visible;"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; letter-spacing: 1.5px; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial; visibility: visible;"><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; visibility: visible; overflow-wrap: break-word !important;"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent; visibility: visible;"><section data-role="title" data-tools="135編輯器" data-id="110073" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(68, 91, 106);"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: left;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: inline-block;"><section style="margin: 0px; padding: 0px 7px 0px 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; align-items: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; flex-shrink: 0;"><section style="margin: 7px -9px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 16px; height: 16px; background-color: rgb(5, 70, 144); flex-shrink: 0; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 16px; height: 16px; background-color: rgb(255, 207, 71); flex-shrink: 0; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section data-brushtype="text" style="margin: 0px 0px 0px 12px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 14px; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">二、類器官培養的生長因子的設計</strong> </section></section><section data-width="100%" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 274.5px; height: 1px; background-color: rgb(5, 70, 144); overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section></section></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 56px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">為了成功建立類器官，必須仔細考慮不同的可用方案，除了所需的生物材料基質外，還需要考慮添加細胞培養、增殖及分化所必需的生長因子，從而保證類器官中的干細胞長期生存的能力。這些生長因子模擬生理組織自我更新或損傷修復過程中的干細胞巢環境，可以通過優化培養物生長條件來實現，如提供基底膜基質（即Matrigengel）并添加一系列激動劑（如Wnt和酪氨酸激酶受體）和抑制劑（如骨形態發生蛋白/轉化生長因子－β）。這些生長因子會因所用類器官干細胞的性質而有所差異，研究人員仍在不斷改進生長因子的添加配方，以進一步提高類器官體外存活率。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 56px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">在類器官中加入必要的生長因子，有助于干細胞在體外更好地增殖分化，從而形成類器官。例如，2009年Hans Clevers實驗室將來自小鼠腸道的腸道成體干細胞接種于基質膠中，并在培養基中添加R-spondin、Noggin、表皮生長因子等干細胞必要生長因子，才培養出了第一個具有隱窩樣結構的小腸類器官。目前主要在類器官培養中使用的生長因子包括：可支持干細胞增殖分化的生長因子如Wnt-3A、R-spondin-1、Noggin等及小分子抑制劑等。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section data-role="title" data-tools="135編輯器" data-id="8" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section data-brushtype="text" style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: inline-block; width: auto; color: rgb(5, 70, 144); font-size: 18px; letter-spacing: 2px; line-height: 1.75em; border-bottom: 1px dotted rgb(5, 70, 144); border-top-color: rgb(5, 70, 144); border-left-color: rgb(5, 70, 144); border-right-color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">1.Wnt信號通路相關促干細胞增殖的細胞因子</strong></span> </section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">Wnt-3A是Wnt/β-catenin信號通路的激活因子，可以促進干細胞增殖分化，也在腫瘤發生中發揮重要作用。目前，Wnt-3A已被報道用于腦類器官及肝臟類器官培養基，除了Wnt-3A外，R-spondin-1是Lgr5的配體，而Lgr5陽性的干細胞已被證實具有擴增成為類器官的潛能。同時，R-spondin-1作為Wnt信號通路的激動劑，可以通過增強Wnt信號在多方面發揮作用。因此，在乳腺類器官、小腸類器官、肝臟類器官等多個類器官的培養過程中均發揮重要作用，是類器官培養中最常見的生長因子之一。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: center; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;"></span> </p><p style="text-align: center"><img style="max-width:800px;max-height:300%;" src="https://img69.chem17.com/9/20230420/638175943723552929472.png" title="640 (3).png" alt="640 (3).png"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: center; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;"></span><br/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: center; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 14px; color: rgb(136, 136, 136);">Wnt/β-catenin信號通路</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">骨形態發生蛋白4(BMP4）是TGF－β超家族的一員，在細胞增殖分化中發揮重要作用可以抑制Wnt信號，從而控制干細胞的自我更新。BMP4被廣泛用于腸道類器官的研究，調節腸道內分泌細胞的激素水平。Noggin也是TGF-β超家族的一員，可以與 BMP4、BMP7結合，是骨形態發生蛋白抑制劑的分泌蛋白，與骨形態發生蛋白起到相反的作用。Noggin與骨形態發生蛋白結合可以協調 Wnt信號激活干細胞，促進其增殖。因此，Noggin已經被廣泛應用于各種類器官的長期培養，如肝臟類器官、小腸類器官及輸卵管類器官。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section data-role="title" data-tools="135編輯器" data-id="8" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section data-brushtype="text" style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: inline-block; width: auto; color: rgb(5, 70, 144); font-size: 18px; letter-spacing: 2px; line-height: 1.75em; border-bottom: 1px dotted rgb(5, 70, 144); border-top-color: rgb(5, 70, 144); border-left-color: rgb(5, 70, 144); border-right-color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">2.促細胞生長因子</strong></span> </section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">表皮生長因子（epidermalgrowth factor，EGF）主要促進細胞的增殖，已被報道在輸卵管類器官及小腸類器官中發揮促進類器官生長發育的重要作用。成纖維細胞生長因子（FGF）可抑制骨形態發生蛋白，從而促進類器官生長。目前，FGF2、FGF7和FGF10是常用于類器官研究的家族成員，對類器官中多種干細胞的增殖分化具有重要的調控作用。血管內皮生長因子（VEGF）不僅在類器官的血管生成及內皮細胞生長中發揮重要作用，還可以促進腎臟類器官的干細胞增殖，增強心臟類器官的心臟功能，促進腦類器官的神經分化等，因此被廣泛用于促進類器官擴增與微環境調控。肝細胞生長因子不僅可以促進肝臟類器官的形成，還可以維持胃類器官和小腸類器官的生長。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"></strong><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: center; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 14px; font-family: 宋體;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(136, 136, 136);"></span></span> </p><p style="text-align: center"><img src="https://img61.chem17.com/9/20230420/638175943843123460534.jpg" style="width:800px;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: center; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 14px; font-family: 宋體;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(136, 136, 136);">VEGF信號通路</span></span><br/> </p><section data-role="title" data-tools="135編輯器" data-id="8" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section data-brushtype="text" style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: inline-block; width: auto; color: rgb(5, 70, 144); font-size: 18px; letter-spacing: 2px; line-height: 1.75em; border-bottom: 1px dotted rgb(5, 70, 144); border-top-color: rgb(5, 70, 144); border-left-color: rgb(5, 70, 144); border-right-color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">3.小分子抑制劑子</strong></span> </section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">除了上述生長因子，還有各種小分子抑制劑被添加至類器官培養基中，如CHIR99021、Y-27632、A83-01和SB431542，它們通過特異性地阻斷或激活各種信號通路，對干細胞的自我更新和增殖起到重要作用。目前已被添加于多個類器官培養基中，可以防止細胞凋亡并促進類器官形成。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">對于小鼠培養體系而言，成熟的腸道干細胞亞群多從Lgr5驅動子后表達eGFP的小鼠中分離提??；而對于人源培養體系而言，胚胎干細胞（embryonic stem cells,ESCs）及誘導多能干細胞（induced pluripotent stem cells,iPSCs）均可用于腸道干細胞的分離培養（Spence et al., 2011)。根據所用的實驗方法不同，培養物表現出的特性有輕微差異，干細胞來源的稱為“類器官"(organoids)，而隱窩來源的稱為“類腸道"(enteroids)( Wells and Spence, 2014 )。有研究者為鑒別不同的體外腸道培養物提出了新的命名法（Stelzner et al ., 2012 )，但目前多數文獻均使用“類器官"統稱這種新型的體外三維培養物。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">相較于從隱窩中培養類器官，從單個干細胞培養類器官更復雜、更耗時、更昂貴，且需要特殊的實驗器材。因此，單個干細胞進行類器官培養一般僅用于干細胞生物學研究，而相對簡單地用隱窩進行類器官培養則廣泛應用于其他類型研究。例如，野生型和轉基因小鼠的腸隱窩可進行類器官培養，并作為一種新型的“細胞系"廣泛應用于基礎研究中。此外，從隱窩培養腸道類器官是研究營養和藥物攝?。⊿ato and Clevers, 2013b）以及腸促胰島素激素分泌的最佳模型（Zietek et al .,2015 )。使用標準實驗室設備在幾小時內即可實現以腸隱窩為基礎的類器官培養，商業化即用型培養基也使得類器官培養更加容易。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 27px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">廈門?；镄∈笮∧c類器官培養基套裝是一款用于建立和維持小鼠腸道成體干細胞來源小腸類器官的wanquan培養基。生長在該wanquan培養基中的小鼠小腸類器官主要由干細胞、腸祖細胞和腸絨毛細胞、潘氏細胞、杯狀細胞和少量腸內分泌細胞組成，在自我更新能力、組織結構、細胞類型和功能方面，小鼠小腸類器官重現了體內小腸上皮的特征。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 27px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span> </p><section data-tools="135編輯器" data-id="123432" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; align-items: center;"><section style="margin: 0px 0px 0px 10px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong data-brushtype="text" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">?；镄∈笮∧c類器官專用培養套裝</strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong data-brushtype="text" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"></strong></span> </section></section><section data-width="80%" style="margin: -5px 0px 0px 15px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 436.797px; height: 1px; background-color: rgb(5, 70, 144); overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section><section style="margin: 25px 0px 0px; padding: 0px 0px 8px 8px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; border-left: 1px solid rgb(5, 70, 144); border-bottom: 1px solid rgb(5, 70, 144);"><p style="text-align: center"><img src="https://img64.chem17.com/9/20230420/638175941701970214114.jpg" style="width:800px;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br/> </p></section></section></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; text-align: left; color: rgb(68, 91, 106); visibility: visible; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 14px; flex-shrink: 0; visibility: visible; font-family: system-ui, -apple-system, BlinkMacSystemFont, Arial, sans-serif;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; background-color: rgb(5, 70, 144); overflow: hidden; visibility: visible;"><section data-tools="135編輯器" data-id="121531" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 0px; padding: 15px 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; border-width: 1px; border-style: solid; border-color: rgb(5, 70, 144); visibility: visible;"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; line-height: 1.75em; visibility: visible;"><section data-tools="135編輯器" data-id="119886" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 20px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; visibility: visible;"><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144); visibility: visible;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;">和，類器官培養基自己配好還是購買商品化培養好</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); visibility: visible; transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255); visibility: visible;"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent; visibility: visible;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(0, 0, 0); line-height: 1.6em; visibility: visible; font-size: 15px; font-family: Helvetica, Arial, sans-serif;">作為生命科學研究常用且重要的方法，細胞體外培養技術直接影響了研究結果的準確性。傳統二維細胞培養模型，藥物無差別作用于每個細胞。細胞間作用力弱，類型單一，細胞貼壁生長，無法模擬體內的生長環境和空間結構。類器官培養不僅高度模擬體內細胞生長環境，保持細胞生長結構，擁有器官的部分功能特性，能更好地代表組織器官的生理功能和生物學特性。但現階段許多類器官原代建立尚存在成功率低，培養條件不穩定的情況。而使用合適、優秀的類器官培養基不僅是類器官培養成功的一大關鍵，還能省時省力節約科研成本。今天我們來聊聊類器官的培養基。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section></section></section></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">用什么替代動物模型</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255);"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">參考資料</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[1]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; caret-color:red font-family: Helvetica, Arial, sans-serif;">https://modernizetesting.org/congress-eliminates-1930s-animal-testing-requirement</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[2]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">https://www.science。。ｏｒｇ/content/article/fda-no-longer-needs-require-animal-tests-human-drug-trials#.Y76rZYPSO3g.twitter</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[3]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: justify; caret-color:red font-family: Helvetica, Arial, sans-serif;">https://science.sciencemag.org/content/371/6531/839</span></span> </p></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[4]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">https://medicalxpress.com/news/2022-02-infusion-3d-cellular-intestine.html</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section data-tools="135編輯器" data-id="122329" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section data-width="100%" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 0px; height: 0px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section><section style="margin: 0px; padding: 10px 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: center; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 15px;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(218, 42, 47); text-align: center;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(127, 127, 127); font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">?；惼鞴倥囵B案例</strong></span> </section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 15px;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; line-height: 1.75em; color: rgb(71, 71, 71);"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">關于?；?/strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255);"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; color: rgb(38, 38, 38); font-size: 15px; font-family: Helvetica, Arial, sans-serif;">廈門?；锟萍加邢薰荆╔iamen Mogengel）位于中國·廈門國家高新技術創業中心；公司致力于3D細胞培養核心原材料的研發與產業化升級，是國內一家從科研做起，從實驗研究中一路走來的全流程自主研發、自主生產的企業。目前公司的產品有基質膠、類器官培養基、細胞因子、3D細胞培養耗材、3D細胞培養智能顯微鏡等；公司擁有4大技術研發中心：分子克隆和細胞編輯中心、實驗動物中心、蛋白表達和純化平臺、類器官質檢系統和自動化。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; color: rgb(38, 38, 38); font-size: 15px; font-family: Helvetica, Arial, sans-serif;"> 團隊擁有十余年類器官技術研究基礎，實力雄厚，科研意志堅定，學術態度嚴謹，大膽嘗試，勇于創新。公司推出的基質膠、類器官培養試劑盒等產品廣泛適用于類器官培養、血管生成實驗、細胞侵襲（transwell）實驗、PDX、CDX模型實驗、腫瘤球培養、腫瘤移植、皮下成瘤實驗、干細胞培養及細胞分化研究等。</span> </p></section></section></section></section></section></section></section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: Helvetica, Arial, sans-serif; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">下期預告</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 14px; display: flex; align-items: center; font-family: system-ui, -apple-system, BlinkMacSystemFont, Arial, sans-serif;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); overflow: hidden; transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">如何分離隱窩并培養腸道類器官</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; color: rgb(68, 91, 106); font-size: 14px; font-family: system-ui, -apple-system, BlinkMacSystemFont, Arial, sans-serif; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; text-align: left; color: rgb(68, 91, 106); visibility: visible; font-family: system-ui, -apple-system, BlinkMacSystemFont, Arial, sans-serif; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 14px; flex-shrink: 0; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; background-color: rgb(5, 70, 144); overflow: hidden; visibility: visible;"><section data-tools="135編輯器" data-id="121531" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 0px; padding: 15px 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; border-width: 1px; border-style: solid; border-color: rgb(5, 70, 144); visibility: visible;"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; line-height: 1.75em; visibility: visible;"><section data-tools="135編輯器" data-id="119886" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 20px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; visibility: visible;"><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144); visibility: visible;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;">和，類器官培養基自己配好還是購買商品化培養好</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); visibility: visible; transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255); visibility: visible;"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent; visibility: visible;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(0, 0, 0); line-height: 1.6em; visibility: visible; font-size: 15px; font-family: Helvetica, Arial, sans-serif;">作為生命科學研究最常用且最重要的方法，細胞體外培養技術直接影響了研究結果的準確性。傳統二維細胞培養模型，藥物無差別作用于每個細胞。細胞間作用力弱，類型單一，細胞貼壁生長，無法模擬體內的生長環境和空間結構。類器官培養不僅高度模擬體內細胞生長環境，保持細胞生長結構，擁有器官的部分功能特性，能更好地代表組織器官的生理功能和生物學特性。但現階段許多類器官原代建立尚存在成功率低，培養條件不穩定的情況。而使用合適、優秀的類器官培養基不僅是類器官培養成功的一大關鍵，還能省時省力節約科研成本。今天我們來聊聊類器官的培養基。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section></section></section></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">用什么替代動物模型</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255);"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">參考資料</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[1]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; caret-color:red font-family: Helvetica, Arial, sans-serif;">https://modernizetesting.org/congress-eliminates-1930s-animal-testing-requirement</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[2]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">https://www.science。。ｏｒｇ/content/article/fda-no-longer-needs-require-animal-tests-human-drug-trials#.Y76rZYPSO3g.twitter</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[3]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: justify; caret-color:red font-family: Helvetica, Arial, sans-serif;">https://science.sciencemag.org/content/371/6531/839</span></span> </p></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[4]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">https://medicalxpress.com/news/2022-02-infusion-3d-cellular-intestine.html</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section data-tools="135編輯器" data-id="122329" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section data-width="100%" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 0px; height: 0px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section><section style="margin: 0px; padding: 10px 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: center; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 15px;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(218, 42, 47); text-align: center;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(127, 127, 127); font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">?；惼鞴倥囵B案例</strong></span> </section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 15px;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; line-height: 1.75em; color: rgb(71, 71, 71);"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">關于?；?/strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255);"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; color: rgb(38, 38, 38); font-size: 15px; font-family: Helvetica, Arial, sans-serif;">廈門?；锟萍加邢薰荆╔iamen Mogengel）位于中國·廈門國家高新技術創業中心；公司致力于3D細胞培養核心原材料的研發與產業化升級，是國內一家從科研做起，從實驗研究中一路走來的全流程自主研發、自主生產的企業。目前公司的產品有基質膠、類器官培養基、細胞因子、3D細胞培養耗材、3D細胞培養智能顯微鏡等；公司擁有4大技術研發中心：分子克隆和細胞編輯中心、實驗動物中心、蛋白表達和純化平臺、類器官質檢系統和自動化。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; color: rgb(38, 38, 38); font-size: 15px; font-family: Helvetica, Arial, sans-serif;"> 團隊擁有十余年類器官技術研究基礎，實力雄厚，科研意志堅定，學術態度嚴謹，大膽嘗試，勇于創新。公司推出的基質膠、類器官培養試劑盒等產品廣泛適用于類器官培養、血管生成實驗、細胞侵襲（transwell）實驗、PDX、CDX模型實驗、腫瘤球培養、腫瘤移植、皮下成瘤實驗、干細胞培養及細胞分化研究等。</span> </p></section></section></section></section></section></section></section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">參考文獻</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 14px; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); overflow: hidden; transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section></section><p style="text-align: center"><img src="https://img69.chem17.com/9/20230420/638175941946638751582.png" style="width:800px;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: center; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; text-align: left; color: rgb(68, 91, 106); visibility: visible; font-family: system-ui, -apple-system, BlinkMacSystemFont, Arial, sans-serif; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 14px; flex-shrink: 0; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; background-color: rgb(5, 70, 144); overflow: hidden; visibility: visible;"><section data-tools="135編輯器" data-id="121531" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 0px; padding: 15px 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; border-width: 1px; border-style: solid; border-color: rgb(5, 70, 144); visibility: visible;"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; line-height: 1.75em; visibility: visible;"><section data-tools="135編輯器" data-id="119886" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 20px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; visibility: visible;"><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144); visibility: visible;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;">和，類器官培養基自己配好還是購買商品化培養好</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center; visibility: visible;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); visibility: visible; transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; visibility: visible;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255); visibility: visible;"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent; visibility: visible;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(0, 0, 0); line-height: 1.6em; visibility: visible; font-size: 15px; font-family: Helvetica, Arial, sans-serif;">作為生命科學研究最常用且最重要的方法，細胞體外培養技術直接影響了研究結果的準確性。傳統二維細胞培養模型，藥物無差別作用于每個細胞。細胞間作用力弱，類型單一，細胞貼壁生長，無法模擬體內的生長環境和空間結構。類器官培養不僅高度模擬體內細胞生長環境，保持細胞生長結構，擁有器官的部分功能特性，能更好地代表組織器官的生理功能和生物學特性。但現階段許多類器官原代建立尚存在成功率低，培養條件不穩定的情況。而使用合適、優秀的類器官培養基不僅是類器官培養成功的一大關鍵，還能省時省力節約科研成本。今天我們來聊聊類器官的培養基。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section></section></section></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">用什么替代動物模型</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255);"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">參考資料</strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[1]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; caret-color:red font-family: Helvetica, Arial, sans-serif;">https://modernizetesting.org/congress-eliminates-1930s-animal-testing-requirement</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[2]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">https://www.science。。ｏｒｇ/content/article/fda-no-longer-needs-require-animal-tests-human-drug-trials#.Y76rZYPSO3g.twitter</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 0em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[3]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: justify; caret-color:red font-family: Helvetica, Arial, sans-serif;">https://science.sciencemag.org/content/371/6531/839</span></span> </p></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">[4]</span></strong></span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; font-family: Helvetica, Arial, sans-serif;">https://medicalxpress.com/news/2022-02-infusion-3d-cellular-intestine.html</span></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><section data-tools="135編輯器" data-id="122329" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important;"><section data-width="100%" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 0px; height: 0px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section><section style="margin: 0px; padding: 10px 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: center; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 15px;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(218, 42, 47); text-align: center;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(127, 127, 127); font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">?；惼鞴倥囵B案例</strong></span> </section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 15px;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; line-height: 1.75em; color: rgb(71, 71, 71);"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p></section></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; justify-content: flex-start;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; flex-shrink: 0;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 24px; overflow: hidden;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 16px; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">關于?；?/strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section><section style="margin: 10px 0px 0px; padding: 10px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(255, 255, 255);"><section data-autoskip="1" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; background: transparent;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; color: rgb(38, 38, 38); font-size: 15px; font-family: Helvetica, Arial, sans-serif;">廈門?；锟萍加邢薰荆╔iamen Mogengel）位于中國·廈門國家高新技術創業中心；公司致力于3D細胞培養核心原材料的研發與產業化升級，是國內一家從科研做起，從實驗研究中一路走來的全流程自主研發、自主生產的企業。目前公司的產品有基質膠、類器官培養基、細胞因子、3D細胞培養耗材、3D細胞培養智能顯微鏡等；公司擁有4大技術研發中心：分子克隆和細胞編輯中心、實驗動物中心、蛋白表達和純化平臺、類器官質檢系統和自動化。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.6em; color: rgb(38, 38, 38); font-size: 15px; font-family: Helvetica, Arial, sans-serif;"> 團隊擁有十余年類器官技術研究基礎，實力雄厚，科研意志堅定，學術態度嚴謹，大膽嘗試，勇于創新。公司推出的基質膠、類器官培養試劑盒等產品廣泛適用于類器官培養、血管生成實驗、細胞侵襲（transwell）實驗、PDX、CDX模型實驗、腫瘤球培養、腫瘤移植、皮下成瘤實驗、干細胞培養及細胞分化研究等。</span> </p></section></section></section></section></section></section></section></section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; color: rgb(5, 70, 144);"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; font-family: Helvetica, Arial, sans-serif;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">關于?；?/strong></span> </section><section style="margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; font-size: 14px; display: flex; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 7px; height: 14px; border-left: 1px solid rgb(5, 70, 144); border-right: 1px solid rgb(5, 70, 144); overflow: hidden; transform: skew(-30deg);"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/> </section></section></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;">廈門?；锟萍加邢薰荆╔iamen Mogengel）位于中國·廈門國家高新技術創業中心。公司致力于3D細胞培養核心原材料的研發與產業化升級。目前公司的產品有基質膠、類器官培養基、細胞因子、3D細胞培養耗材、3D細胞培養智能顯微鏡等。公司擁有4大技術研發中心：分子克隆和細胞編輯中心、實驗動物中心、蛋白表達和純化平臺、類器官質檢系統和自動化。</span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; text-indent: 28px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;"><br style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"/></span> </p><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: left; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; line-height: 1.6em; visibility: visible; font-family: Helvetica, Arial, sans-serif;"> 團隊擁有十余年類器官技術研究基礎，實力雄厚，科研意志堅定，學術態度嚴謹，大膽嘗試，勇于創新。公司推出的基質膠、類器官培養試劑盒等產品廣泛適用于類器官培養、血管生成實驗、細胞侵襲（transwell）實驗、PDX、CDX模型實驗、腫瘤球培養、腫瘤移植、皮下成瘤實驗、干細胞培養及細胞分化研究以及其他待開發實驗類型。</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: justify;"></span> </p></section></section></section></section></section></section><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; color: rgba(0, 0, 0, 0.9); font-family: system-ui, -apple-system, BlinkMacSystemFont, " helvetica="" pingfang="" hiragino="" sans="" microsoft="" yahei="" font-size:="" letter-spacing:="" white-space:="" 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